Dear Representative Rines:

I am writing in support of LD 429, An Act to Require Veterinarians to Provide Vaccine Disclosure Forms. I do so as a veterinary research/clinician scientist, who has been actively involved in vaccination issues for more than 40 years.

Background

While vaccines have significantly reduced the incidence of serious infectious diseases over the years, increasing evidence implicates vaccines in triggering immune-mediated and other chronic disorders. The duration of immunity from vaccination is now accepted to be at least 5 or more years for the clinically important diseases of dogs and cats. Accordingly, new vaccine protocols are recommended: 1) giving the puppy or kitten vaccine series followed by a booster at one year of age; 2) administering further boosters in a combination vaccine every three years or as split components alternating every other year until; 3) the pet reaches geriatric age, when booster vaccination is often unnecessary and may be inadvisable. In the years between or instead of boosters, serum vaccine antibody titers can be measured to determine the adequacy of immune memory.

Vaccine antibody titer testing measures antibodies to certain diseases to determine whether an animal’s immune system has responded to previous vaccinations. This blood test helps determine whether or not an animal will be protected from the infectious disease if he/she were to be exposed. Titers do not distinguish between immunity generated by vaccination and/or exposure to the disease, although the magnitude of immunity produced just by vaccination is usually lower. Reliable serologic vaccine titering is available from several university and commercial laboratories and the cost is reasonable. If a given animal’s humoral immune response has fallen below levels of adequate immune memory, an appropriate vaccine booster can be administered.

Duration of immunity (DOI) from challenge studies
Cats

Challenge studies in the cat from Cornell University following just two doses of trivalent killed vaccine given at 8 and 12 weeks of age, showed complete protection from feline panleukopenia virus for more than 8 years, and good protection against feline calicivirus and herpes virus for 4 and 3 years, respectively. Colorado State University recently reported long term vaccinal immunity in a large number of pet and laboratory cats.

Dogs

The 2003 report of the AAHA Canine Vaccine Task Force indicated that the DOI following challenge studies in dogs was equal to or greater than 7 years for the three canine “core” vaccines against distemper virus (CDV), parvovirus (CPV-2) and adenovirus (hepatitis, CAV-1).

Challenge of immunity studies have shown that the minimum DOI of modified live virus (MLV) CDV vaccines are 7 and 5 years for the Rockborn and Onderstepoort strains of CDV, respectively. Challenge of immunity studies for CPV-2 vaccines have shown the minimum DOI with MLV CPV-2 vaccines to be 7 years. Challenge of immunity studies for CAV-1 have shown the minimum DOI with modified live CAV-2 vaccines to be 7 years. Based on serologic data for sterilizing immunity, the minimum DOI for CDV is 12-15 and 9 years, respectively, for the Rockborn and Onderstepoort strains of CDV; up to 10 years for CPV-2; and at least 9 years for CAV-1.

In 2002, the AVMA Council on Biologic and Therapeutic Agents (COBTA) published a landmark report on cat and dog vaccines. Some key features of that report were: “vaccination is a potent medical procedure associated with benefits and risks for animals; considerations of exposure probability, susceptibility, severity of the disease, efficacy and safety of the vaccine, potential public health concerns, and owners preferences are appropriate; individual animals will require different vaccines and vaccination programs; revaccination recommendations should be designed to create and maintain clinically relevant immunity, while minimizing adverse event potential; the practice of revaccinating animals annually is largely based on historic precedent supported by minimal scientific data; unnecessary stimulation of the immune system does not result in enhanced disease resistance and may expose animals to unnecessary risks; veterinarians should consider creating a core vaccination program for most of the animals in their practice area; core vaccines are defined as vaccines appropriate to provide protection in most animals against diseases that pose a risk of severe disease because the pathogens are virulent, highly infectious, and widely distributed in the region; current adverse event reporting systems need substantial improvement in the capture, analysis, and dissemination of information; practitioner commitment to reporting adverse events and practitioner access to timely analyses of adverse event data are essential to providing optimal animal care.”

In 2004, the following statement was endorsed by all 23 members of the ACVIM Infectious Disease Study Group and approved by the ACVIM Board: “The American College of Veterinary Internal Medicine believes that all dogs should have a routine health examination by a veterinarian at least yearly. At that time, vaccination needs should be determined and only those antigens deemed necessary should be administered. We currently endorse the use of the AAHA [American Animal Hospital Association] 2003 Canine Vaccine Guidelines as an aid in determining the vaccination needs of individual dogs.“

Finally, because of the potential legal liability for all medical procedures including vaccination, veterinarians need to obtain informed consent from their clients. This means that clients need to be given information about the benefits and risks of vaccination in order to permit them to make an appropriate decision about the individual vaccine to be selected and the vaccination programs of choice. Thus, obtaining informed consent and the client’s signature on a consent form or patient chart is an important aspect of following the legal standards of duty to inform ”what any reasonable, prudent person would want to know about the subject”.

I hope that this brief summary of a complex issue will be helpful.

Sincerely,

<signature on file>

W. Jean Dodds, DVM
President
www.Hemopet.com

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References

Cohen, A.D. and Shoenfeld, Y. Vaccine-induced autoimmunity. J. Autoimmunity 9: 699-703, 1996.
Dodds WJ. More bumps on the vaccine road. Adv Vet Med 41:715-732, 1999.
Dodds WJ. Vaccination protocols for dogs predisposed to vaccine reactions. J Am An Hosp Assoc 38: 1-4, 2001.
Duval D, Giger U. Vaccine-associated immune-mediated hemolytic anemia in the dog. J Vet Intern Med 10:290-295, 1996.
Flemming DD, Scott JF. The informed consent doctrine: what veterinarians should tell their clients. OJ Am Vet Med Assoc 224: , 2004.
Grubb DJ, Chapman C. The vaccine quandary. AAHA Trends Magazine Dec 2003, pp. 35-38.
Hogenesch H, Azcona-Olivera J, Scott-Moncreiff C, et al. Vaccine-induced autoimmunity in the dog. Adv Vet Med 41: 733-744, 1999.
Hustead DR, Carpenter T, Sawyer DC, et al. Vaccination issues of concern to practitioners. J Am Vet Med Assoc 214: , 1999.
Klingborg DJ, Hustead DR, Curry-Galvin E, et al. AVMA Council on Biologic and Therapeutiv Agents’ report on cat and dog vaccines. J Am Vet Med Assoc 221: , 2002.
Lappin MR, Andrews J, Simpson D, et al. Use of serologic tests to predict resistance to feline herpesvirus 1, feline calicivirus, and feline parvovirus infection in cats. J Am Vet Med Assoc 220: 38-42, 2002.
McGaw DL, Thompson M, Tate, D, et al. Serum distemper virus and parvovirus antibody titers among dogs brought to a veterinary hospital for revaccination. J Am Vet Med Assoc 213: 72-75, 1998.
Moore GE, Glickman LT. A perspective on vaccine guidelines and titer tests for dogs. J Am Vet Med Assoc 224: .
Mouzin DE, Lorenzen M J, Haworth, et al. Duration of serologic response to five viral antigens in dogs. J Am Vet Med Assoc 224: 55-60, 2004.
Mouzin DE, Lorenzen M J, Haworth, et al. Duration of serologic response to three viral antigens in cats. J Am Vet Med Assoc 224: 61-66, 2004.
Paul MA. Credibility in the face of controversy. Am An Hosp Assoc Trends Magazine XIV(2):19-21, 1998.
Paul MA (chair) et al. Report of the AAHA Canine Vaccine Task Force: 2003 canine vaccine guidelines, recommendations, and supporting literature. AAHA, April 2003, 28 pp.
Schultz RD. Current and future canine and feline vaccination programs. Vet Med 93:233-254, 1998.
Schultz RD, Ford RB, Olsen J, Scott F. Titer testing and vaccination: a new look at traditional practices. Vet Med, 97: 1-13, 2002 (insert).
Scott FW, Geissinger CM. Long-term immunity in cats vaccinated with an inactivated trivalent vaccine. Am J Vet Res 60: 652-658, 1999.
Scott-Moncrieff JC, Azcona-Olivera J, Glickman NW, et al. Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs. J Am Vet Med Assoc 221: 515-521, 2002.
Smith CA. Are we vaccinating too much? J Am Vet Med Assoc 207:421-425, 1995.
Tizard I, Ni Y. Use of serologic testing to assess immune status of companion animals. J Am Vet Med Assoc 213: 54-60, 1998.
Twark L, Dodds WJ. Clinical application of serum parvovirus and distemper virus antibody titers for determining revaccination strategies in healthy dogs. J Am Vet Med Assoc 217:, 2000.

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W. JEAN DODDS

RÉSUMÉ

Dr. Dodds received the D.V.M. degree with honors in 1964 from the Ontario Veterinary College, University of Toronto. In 1965 she accepted a position with the New York State Health Department in Albany and began comparative studies of animals with inherited and acquired bleeding diseases. Her position there began as a Research Scientist and culminated as Chief, Laboratory of Hematology, Wadsworth Center. In 1980 she also became Executive Director, New York State Council on Human Blood and Transfusion Services. This work continued full-time until 1986 when she moved to Southern California to establish Hemopet, the first nonprofit national blood bank program for animals.

From , she was a member of many national and international committees on hematology, animal models of human disease, veterinary medicine, and laboratory animal science. Dr. Dodds was a grantee of the National Heart, Lung, and Blood Institute (NIH) and has over 150 research publications. She was formerly President of the Scientist's Center for Animal Welfare; and Chairman of the Committee on Veterinary Medical Sciences and Vice-Chairman of the Institute of Laboratory Animal Resources, National Academy of Sciences. In 1974 Dr. Dodds was selected as Outstanding Woman Veterinarian of the Year, AVMA Annual Meeting, Denver, Colorado; in 1977 received the Region I Award for Outstanding Service to the Veterinary Profession from the American Animal Hospital Association, Cherry Hill, New Jersey; in 1978 and 1990 received the Gaines Fido Award as Dogdom's Woman of the Year; and the Award of Merit in 1978 in Recognition of Special Contributions to the Veterinary Profession from the American Animal Hospital Association, Salt Lake City, Utah. In 1984 she was awarded the Centennial Medal from the University of Pennsylvania School of Veterinary Medicine. In 1987 she was elected a distinguished Practitioner of the National Academy of Practice in Veterinary Medicine. In 1994 she was given the Holistic Veterinarian of the Year Award from the American Holistic Veterinary Medical Association. She is an active member of numerous professional societies.

Today, Dr. Dodds is actively expanding Hemopet's range of nonprofit services and educational activities. The animal blood bank program provides canine blood components, blood bank supplies, and related services throughout North America. Hemopet's retired Greyhound blood donors are adopted as pets through the Pet Life-Line arm of the project. On behalf of Hemopet, she consults in clinical pathology nationally and internationally, and regularly travels to teach animal health care professionals, companion animal fanciers, and pet owners on hematology and blood banking, immunology, endocrinology, nutrition and holistic medicine. She was also the Editor of Advances in Veterinary Science and Comparative Medicine for Academic Press.

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Patents

U.S. Patent 5,196,311	ELISA Test for von Willebrand Factor
U.S. Patent 5,202,264	ELISA Using Multi-Species Antibodies for Detection of von Willebrand Factor in Multiple Species
U.S. Patent 5,486,685	Oven with Food Presence Indicator
U.S. Patent 5,830,709	Detection Method for Homologous Portions of a Class of Substances
U.S. Patent 6,287,254	Animal Health Diagnostics
U.S. Patent 9,419,192	Animal Genetic and Health Profile Database Management
U.S. Patent 9,898,193	Animal Health Care, Well-Being and Nutrition